NGAL (neutrophil gelatinase-associated lipocalin) and cystatin C: Are they good predictors of contrast nephropathy after percutaneous coronary interve

The aim of the study was to assess whether neutrophil gelatinase-associated lipocalin (NGAL) and Cystatin C could predict contrast-induced nephropathy in non-diabetic patients (n = 60, mean age 60 ± 11 years) with normal serum creatinine undergoing elective PCI. We found a significant rise in serum NGAL after 2, 4 and 8 h, and in urinary NGAL after 4, 8 and 24 h after PCI. Cystatin C rose significantly 8 and 24 h after the procedure. Prevalence of CIN was 10%. We found 90% sensitivity and 74% specificity of serum and 76% sensitivity and 80% specificity of urinary NGAL increase. NGAL may represent a sensitive early biomarkers of renal impairment after PCI.

H. Bachorzewska-Gajewskaa, 1, J. Malyszkoa, b, , 1, E. Sitniewskaa, J.S. Malyszkoa, B. Poniatowskia, K. Pawlaka and S. Dobrzycki